Laterality of amblyopia
(La latéralité dans l'amblyopie)
Repka M, Simons K,
Kraker R; Pediatric Eye Disease Investigator Group.
Zanvyl Krieger Children's Eye Care Center, The Wilmer Ophthalmological
Institute, Johns Hopkins Hospital, Baltimore, MD, USA
pedig@jaeb.org
PURPOSE: To
determine the frequency of unilateral amblyopia in right versus left eyes among
children younger than 18 years.
DESIGN: Analysis of data collected in randomized clinical trials
conducted by the Pediatric Eye Disease Investigator Group.
METHODS: The laterality of the amblyopic eye was analyzed in 2635
subjects younger than 18 years who participated in 9 multicenter prospective,
randomized treatment trials. Eligibility criteria for these clinical trials
included unilateral amblyopia associated with strabismus, anisometropia, or both,
with visual acuity between 20/40 and 20/400. Logistic regression was used to
assess the association of baseline and demographic factors with the laterality
of amblyopia.
RESULTS: Among subjects with anisometropic amblyopia (with or without
strabismus), amblyopia was present more often in left than right eyes, with a
relative prevalence of 59% in left eyes (95% confidence interval, 57% to 62%; P
< .001 from a test of proportion, 50%). However, among subjects with
strabismic-only amblyopia, there was no laterality predilection (relative
prevalence of 50% in left eyes; 95% confidence interval, 47% to 54%; P = .94).
CONCLUSIONS: Anisometropic amblyopia, with or without strabismus, occurs
more often in left eyes than right eyes. This finding of amblyopia laterality
may be related to microtropia, sighting dominance, or other forms of ocular
dominance; developmental or neurological factors; laterality in the development
of refractive error; or a combination thereof.
Retour à la bibliographie d'août 2010
(Dernière mise à jour de cette page le 25/09/10)